Presynaptic NMDA receptors also make the switch
نویسندگان
چکیده
منابع مشابه
Developmental switch in the contribution of presynaptic and postsynaptic NMDA receptors to long-term depression.
NMDA receptor (NMDAR) activation is required for many forms of learning and memory as well as sensory system receptive field plasticity, yet the relative contribution of presynaptic and postsynaptic NMDARs over cortical development remains unknown. Here we demonstrate a rapid developmental loss of functional presynaptic NMDARs in the neocortex. Presynaptic NMDARs enhance neurotransmitter releas...
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The N-methyl-D-aspartate (NMDA) receptor plays an essential role in excitatory transmission, synaptic integration, and learning and memory. In the classical view, postsynaptic NMDA receptors act as canonical coincidence detectors providing a 'molecular switch' for the induction of various forms of short- and long-term synaptic plasticity. Over the past twenty years there has been accumulating e...
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Previous investigations in our laboratory revealed that N-methyl-D-aspartate (NMDA) and L-glutamate stimulate [3H]noradrenaline release in rat brain cortex slices (Fink et al., 1989; G&hert and Fink, 1989). However, the exact location of the NMDA receptor involved remained unclear. Tetrodotoxin strongly reduced the stimulatory effect of NMDA but failed to completely abolish it. This finding wou...
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The nucleus accumbens shell (NAc) is a key brain region mediating emotional and motivational learning. In rodent models, dynamic alterations have been observed in synaptic NMDA receptors (NMDARs) within the NAc following incentive stimuli, and some of these alterations are critical for acquiring new emotional/motivational states. NMDARs are prominent molecular devices for controlling neural pla...
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glutamatergic system stimulationthe nucleus accumbens shell, may affect anxiety-related behaviors, aversive learning and memory. glutamate receptors are differentially distributed in pre- and postsynaptic sites contributing to neuronal communications.the present study aimed to examine the possible involvement of the nac shell presynaptic nmda receptors on nmda induced responses, using the eleva...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2011
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn0311-274